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Dopamine beta hydroxylase deficiency : ウィキペディア英語版 | Dopamine beta hydroxylase deficiency
Dopamine beta hydroxylase deficiency is a condition involving inadequate Dopamine beta hydroxylase. It is characterized by increased amounts of serum dopamine and the absence of nor-epinephrine and epinephrine. Dopamine is released in place of nor-epinephrine as a false neurotransmitter. This condition is sometimes referred to as norepinephrine deficiency. ==Symptoms== A deficiency of norepinephrine and epinephrine that causes nasal stuffiness, droopy eyelids (ptosis), dizzy head (orthostatic hypotension), and difficulty standing still for longer than one minute among other similar symptoms. Another symptom is hypoglycemia which is thought to be caused by adrenomedullary failure and the T-wave abnormalities from failure of noradrenergic control. Also, prolactin is frequently suppressed by excessive dopamine. Excess dopamine can also affect digestion, producing vomiting and inhibiting motor signaling to the GI tract. This is a form of dysautonomia but differentiated from familial dysautonomia by lack of familial dysautonomic symptoms such as loss of sense of pain and smell.
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